Our Science


Scientists at Life Biosciences regularly publish articles in peer-reviewed journals and publications to inform the scientific community of our research and to contribute to the advancement of research in the field of aging.


Mitochondrial Uncoupling

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Alexopoulos SJ, Chen S-Y, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL. Nat Commun. 2020 May 14; 11, 2397.

6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitis. Salamoun JM, Garcia CJ, Hargett SR, Murray JH, Chen S-Y, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Tucker SP, Hoehn KL, Santos WL. J. Med. Chem. 2020 May 11; 63, 11, 6203–6224.

[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine derivatives as mitochondrial uncouplers for the potential treatment of nonalcoholic steatohepatitis. Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen S-Y, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. J. Med. Chem. 2020 February 4; 63, 5, 2511–2526.

Small molecule mitochondrial uncouplers and their therapeutic potential. Childress ES, Alexopoulos SJ, Hoehn KL, and Santos WL. J. Med. Chem. 2017 November 20; 61, 11, 4641–4655.


Chaperone-Mediated Autophagy

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Cell. 2021 May 13;  184:10, 2525–2796.

Chaperone-mediated autophagy sustains haematopoietic stem-cell function. Dong S, Wang Q, Kao Y-R, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D’Alessandro A, Will B, Cuervo AM. Nature. 2021 January 13; 591, 117–123.

Selective autophagy as a potential therapeutic target for neurodegenerative disorders. Scrivo A, Bourdenx M, Pampliega O, Cuervo AM. The Lancet. 2018 September 1; 17:9, 802–815.

The coming of age of chaperone-mediated autophagy. Kaushik S, Cuervo AM. Nat Rev Mol Cell Biol. 2018 April 6; 19, 365–381.

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM. Nat Chem Biol. 2013 18 October; 9, 374–382.

Balance between autophagic pathways preserves retinal homeostasis. Rodríguez-Muela N, Koga H, García-Ledo L, de la Villa P, de la Rosa EJ, Cuervo AM, Boya P. Aging Cell. 2013 22 March; 12:3, 478-488.


Epigenetic Reprogramming

Reprogramming to recover youthful epigenetic information and restore vision. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang J-H, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Nature. 2020 December 2; 588, 124–129.

In vivo amelioration of age-associated hallmarks by partial reprogramming. Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Esteban CR, Nuñez G, Delicado EN, Campistol JM, Guillen I, Guillen P, Belmonte JCI. Cell. 2016 December 15; 167:7, 1719-1733.

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