Our Science

Targeting the Biology of Aging

Aging is the biggest modifiable risk factor for most chronic diseases and is caused by a discrete number of biological mechanisms that can be targeted therapeutically.

Life Biosciences healthspan

Source: Global Burden of Disease Collaborative Network

A New Approach

Life Biosciences is pursuing indication areas where aging biology has a clear link to disease pathogenesis. We prioritize diseases where there are limited or no available treatment options approved today. We are currently developing therapeutics targeting three biological mechanisms that contribute to aging: Loss of proteostasis, mitochondrial dysfunction, and epigenetic alterations.

Biological Mechanisms of Aging

Source: Lopez-Otin C et al. Cell (2013)

 

Areas of Focus

Each of our platforms is based on science in-licensed from world-leading researchers. These platforms have the potential to prevent, treat, and/or reverse multiple aging-related diseases, each with critical unmet medical needs.

Chaperone-Mediated Autophagy Platform
Developing small molecule activators of chaperone-mediated autophagy that decrease the accumulation of aggregated proteins and have demonstrated safety and efficacy in preclinical models of neurodegeneration and age-related decline in stem cell function
LEARN MORE >

Mitochondrial Uncoupler Platform
Developing small molecule mitochondrial uncoupler compounds that increase metabolic rate and have demonstrated safety and efficacy in preclinical models of obesity and non-alcoholic steatohepatitis (NASH)
LEARN MORE >

Epigenetic Reprogramming Platform
Developing therapies that induce the expression of three Yamanaka factors (OCT4, SOX2 and KLF4 [OSK]) that reprogram the epigenome and have demonstrated safety and efficacy in preclinical nerve crush and glaucoma model
LEARN MORE >