Cellular rejuvenation protects neurons from inflammation-mediated cell death. Drake SS, Mohammadnia A, Zaman A, Gianfelice C, Heale K, Groh AMR, Hua EML, Hintermayer MA, Lu YR, Gosselin D, Zandee S, Prat A, Stratton JA, Sinclair DA, Fournier AE. Cell Reports, 2025; 44.
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Scientists working at or collaborating with Life Biosciences regularly publish articles in peer-reviewed journals to inform the scientific community of our findings and to contribute to the advancement of research in the field.
Epigenetic reprogramming- a novel gene therapy that restores vision loss in a nonhuman primate model of NAION. Ksander B, Shah M, Krasniqi D, Gregory-Ksander MS, Rosenzweig-Lipson S, Broniowska K, Walthier M, Mannick J, Cermak J, Karg M, Shirahama S, Refaian N, Lu Y, Lawrence M, Rizzo JF, Sinclair DA. Invest. Ophthalmol. Vis. Sci. 2023;64(8):474.
Opportunities for cellular rejuvenation in Alzheimer’s disease: how epigenetic reprogramming and chaperone-mediated autophagy are enabling next generation therapeutic approaches. Rosenzweig-Lipson, S. The Journal for Prevention of Alzheimer’s Disease. 2023 October 24; 10, 661–668.
Loss of epigenetic information as a cause of mammalian aging. Yang J, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Ching Chew Y, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O’Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Cell. 2023 January 19; 186;2, 305-326.
Reprogramming to recover youthful epigenetic information and restore vision. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang J-H, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Nature. 2020 December 2; 588, 124–129.
In vivo amelioration of age-associated hallmarks by partial reprogramming. Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Esteban CR, Nuñez G, Delicado EN, Campistol JM, Guillen I, Guillen P, Belmonte JCI. Cell. 2016 December 15; 167:7, 1719-1733.
Sustained vision recovery by OSK gene therapy in a mouse model of glaucoma. Karg MM, Lu YR, Refaian N, Cameron J, Hoffmann E, Hoppe C, Shirahama S, Shah M, Krasniqi D, Krishnan A, Shrestha M, Guo Y, Cermak JM, Walthier M, Broniowska K, Rosenzweig-Lipson S, Gregory-Ksander M, Sinclair DA, Ksander BR. Cellular Reprogramming. 2023;25(6):288-299.
Partial epigenetic reprogramming of RPE cells reverses age and rejuvenates mitochondrial metabolism. Karg M, Shu DY, Lu Y, He Y, Cameron JC, Weissman JS, Bell GW, Sinclair DA, Saint-Geniez M, Ksander B. Invest. Ophthalmol. Vis. Sci. 2023;64(8):2966.
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